Novak Djokovic faces Britain's Kyle Edmund and Roger Federer also starts his title challenge on Friday's packed schedule at the Miami Open.
Djokovic, the defending champion, will take on Edmund in the second round, with the match scheduled to take place at midnight, live on Sky Sports.
The 21-year-old secured his first ever match against the world No 1 after a battling three-set win over Jiri Vesely in the first round.
Edmund has shown he can handle the big stage while playing in the Davis Cup
Djokovic retained his trophy at Indian Wells last week, defeating Milos Raonic in straight sets, and has won four of the last five tournaments in Miami.
But Edmund has performed creditably on the big stage before as he extended world No 15 David Goffin to five sets in a battling singles defeat in last year's Davis Cup final.
Tough comeback for Fed
Roger Federer is fit again after undergoing knee surgery
Federer will make his comeback from a knee injury when he plays a tricky opening match against Juan Martin Del Potro.
The Swiss was forced to undergo surgery after injuring himself while preparing a bath for his daughters, but has quickly returned to fitness.
The 17-time Grand Slam winner will need to be match sharp against Del Potro, a former US open champion, who himself has overcome injury problems.
Federer has 15 wins from his previous 20 matches against Del Potro, but the pair have not shared the court since the world No 3's victory at the 2013 ATP Tour finals.
Best of the rest
Dominic Thiem is one of the sport's upcoming talents
Seventh seed Tomas Berdych takes on American Rajeev Ram, while eighth-seeded David Ferrer has been pitted against another home hope, qualifier Taylor Fritz.
Exciting youngster Dominic Thiem, Richard Gasquet, Marin Cilic and Goffinare part of a packed schedule in Florida.
Possible upset?
Albert Ramos-Vinolas is a potentially tough foe for Richard Gasquet
If Federer is short of fitness then he could struggle at first against Del Potro, but should find a way past the towering Argentine.
Albert Ramos-Vinolas has performed well this year, reaching a tour semi-final, and he claimed an upset win over Nick Kyrgios at Indian Wells.
The Spaniard is capable of pulling off another surprise result against Frenchman Gasquet.
Brit interest
Johanna Konta can follow Heather Watson into the third round
British No 1 Johanna Konta has been drawn against Danka Kovinic in the second round of the women's event.
Konta will be hoping to join Heather Watson, who has already reached the third round with a straight sets win over 20th seeded Sloane Stephens.
